Activated Silk 27P-⍺, Evolved By Nature

Retinol is considered by some as the toxic ex of skin care; in fact, the EU is regulating it above 0.3%. The ingredient has been tolerated because there's been no better option. Enter: Activated Silk 27P-⍺: the biotech glow-up consumers deserve. This silk-derived peptide surpasses retinoic acid and TGF-beta in collagen production — specifically type 1, the "good stuff" that skin loves. With zero irritation, UV drama or tolerance buildup, it offers visible anti-aging efficacy without baggage. Natural, upcycled, cruelty-free and biodegradable, it is also beautifully sustainable. Activated Silk 27P-⍺ offers younger-looking, more youthful skin cells without retinol's risks.

Activated Silk 8A-⍺, Evolved By Nature

Activated Silk 8A-⍺ is a natural brightening, anti-hyperpigmentation peptide that works like a dream. Unlike unstable vitamin C, which poses formulation issues, oxidizing if you look at it wrong, this biotech peptide triggers natural cell turnover, moving post-inflammatory hyperpigmentation up and out while visibly brighter skin takes over. In testing, 100% of users saw improvement: 18% reduction in dark spots, 27% brighter skin, zero irritation and no bleaching risk. It also formulates like water, remains stable and works with skin's natural processes instead of against them. Upcycled, sustainable and effective, Activated Silk 8A-⍺ finally enables the industry move harsh acids and sketchy synthetics up and out of formulas for good.

Aethelis Granata ExoCell, Naolys

Aethelis Granata ExoCell is a botanical exosome-based active that reactivates cellular dialogue to promote skin longevity. Produced via Naolys’ patented plant cell biotechnology in collaboration with the University of Bordeaux, it sustainably delivers pure plant exosomes, biological messengers that trigger SUMOylation, an epigenetic mechanism enhancing DNA repair, ATP production and ECM regeneration. Clinically proven to reduce wrinkle length by 27% and boost hydration by 79%, it visibly revitalizes skin from within. With drastically reduced water use compared to traditional extracts, this eco-conscious innovation offers a powerful, science-backed solution for well-aging skin care.

Angel-Eye EFX, Vantage Specialty Chemicals

Angel-Eye EFX is a COSMOS-approved active ingredient inspired by Traditional Chinese Medicine aimed at preventing aging of the eye area. It works by boosting blood microcirculation, which helps to reduce wrinkles, dark circles and the formation of under-eye bags. A combination of in vitro and in vivo tests have confirmed the efficacy of Angel-Eye EFX for improving eye area skin in 28 days.

Bacillus Lysate, Delavie Sciences

Bacillus Lysate is a patented breakthrough ingredient redefining how skin care approaches protection, hydration and bio-optimization. Originating from an extremophile microorganism proven to survive the harsh conditions of space, this SPF booster enhances skin’s resilience against daily stressors. Clinically proven to act as a powerful antioxidant that sequesters UVA-induced free radicals, stimulate the signaling protein Sirt1 linked to aging, and increase the skin’s natural production of hyaluronic acid for deep hydration, Bacillus Lysate delivers multifunctional performance unlike conventional actives. Exclusive to Delavie Sciences, this ingredient, with its rare origin and validated efficacy, is offered by no other brand.

Bioactive Totarol, Hyperganic

Biogroup Bioactive Totarol is a breakthrough natural active delivering clinically proven anti-aging results with sustainable integrity. In trials, it reduced wrinkle count by 13%, wrinkle area by 6%, and improved skin texture within 56 days. Its antioxidant and anti-inflammatory properties protect against oxidative stress, while also regulating sebum for clearer, more radiant skin. Unlike conventional actives, Bioactive Totarol functions as a natural self-preservative, extending shelf life. Sustainably extracted from fallen tōtara trees via a patented CO₂ process, it represents a next-generation solution: a high-performance, multifunctional ingredient that reduces visible signs of aging while supporting cleaner, greener beauty.

EcoPep, Oat Cosmetics

EcoPep is a revolutionary high-purity natural peptide from Avena sativa (oat), created via a patent-pending, enzyme-based biotechnology process. Clinically proven to make skin look up to 9 years younger in 3 months, EcoPep works on multiple levels — cellular, structural and visual — to restore firmness, improve elasticity and smooth wrinkles. With 90% purity, it delivers exceptional bioavailability at just 0.1% inclusion. Produced through 100% natural, eco-conscious methods, EcoPep isn’t just about looking younger — it’s about keeping skin biologically younger. The future of aging care starts now, with EcoPep leading the revolution in longevity skin care.

Ilumys, Greentech

Ilumys is a skin-perfecting and illuminating natural active with intense anti-dark spot effects. Rich in gingerols, the ingredient is sourced from sustainably grown ginger roots and combines the power of traditional Asian medicine with innovative scientific advances to act directly on two key causes of dark spots: lipofuscin accumulation and melanogenesis imbalance. It also reduces inflammation, oxidative stress and SCF levels, while uniquely targeting melanin production through RGMB neural factors. Ilumys visibly reduces dark spot density (-181%) and skin contrast (-142%), offering a holistic approach to tackle aging dark spots from the root, revealing a more even and luminous complexion.

Kaligen, Kalichem

Kaligen is a next-generation, plant-based biotech ingredient composed of PDRN/DNA (“nucleobiotic” technology) derived through sustainable fermentation by yeast. It delivers high-purity nucleic acids (> 90%) with strong bioavailability, promoting collagen synthesis, cell renewal and skin repair. Building on two decades of PDRN research, Kaligen combines proven regenerative and soothing effects with an eco-conscious approach. It enhances elasticity, firmness and post-treatment recovery while reducing inflammation. Versatile and stable, Kaligen suits anti-wrinkle, skin care, sun care, hair care, makeup and oral care applications. It represents a scientific and sustainable evolution in cosmetic rejuvenation technologies.

LunaRose, Mibelle Biochemisty

LunaRose, derived from fruits of roses that have adapted to Finland’s special day-night cycles, regenerates skin overnight with melatonin-like effects. It boosts melatonin receptor and circadian clock gene expression in the skin; provides antioxidant and skin barrier-strengthening effects; and improves mitochondrial function. Thereby, it enhances skin radiance and hydration while reducing redness, dark eye circles and wrinkles, leading to well-rested and rejuvenated skin overnight. The ingredient has been clinically proven to work after just a single overnight application in sleep-deprived skin and on sleep wrinkles on the décolleté. Based on a unique organic Nordic rose variety, it is also NATRUE certified and COSMOS approved).

TensylPro, Biocogent

TensylPro combines two synergistic botanicals, Rumex acetosella and Pinus massoniana, to restore and reinforce the architecture of the skin. Designed to promote skin health by supporting the dermal-epidermal junction (DEJ) and targeting chronic inflammation, TensylPro stimulates both collagen and elastin production, while also rebuilding essential proteins for long-term anti-aging benefits. TensylPro provides comprehensive skin health and rejuvenation by promoting firmer, plumper and more resilient skin. The synergistic blend of this dual botanical extract makes TensylPro a targeted solution for skin care formulations designed to promote healthy skin aging, skin firming and smoothing benefits while helping to counteract inflammation and wrinkle formation.

Vitaguard A, BASF

Vitaguard A is a next-generation retinol delivery system powered by BASF’s patented solid lipid particle (SLP) technology. Designed to overcome retinol’s instability and irritation challenges, it is capable of high retinol loading (5% pure retinol) and provides greater retinol efficiency and enhanced bioavailability. Vitaguard A demonstrates superior stability — even under real-use conditions — without the need for inert gas or airless packaging, even compared to a commercial retinol encapsulation benchmark. It is a breakthrough in dermocosmetic performance, enabling high-efficacy, efficient formulations for the well-known consumer hero retinol.

Lumenato, Lycored

Lumenato is a standardized yellow tomato extract developed exclusively by Lycored. Derived from a proprietary breed of yellow tomato, Lumenato’s active components — phytoene and phytofluene — are colorless carotenoids scarcely found in nature. These compounds have a unique capacity to protect the skin from UVB radiation. Lumenato works from the inside out to build a reservoir of goodness that supports the building blocks of skin health, repair and recuperation. Backed by four pre-clinical trials and three clinical trials, Lumenato is shown to support skin structure, boosting and protecting collagen and influencing ceramides for improved skin barrier function, hydration, elasticity, firmness and a radiant glow.

PrimaColl, Geltor

PrimaColl is biodesigned for longevity in both ingestible and topical applications. It is the first and only biotech collagen cleared by the FDA with a GRAS "No Questions" letter for ingestible use. A signaling collagen, PrimaColl is rich in domains designed to activate collagen and ECM production for visible results. It is clinically proven to improve skin elasticity, firmness, hydration and wrinkle depth when ingested daily for 12 weeks. Topically, it boosts collagen type I and supports skin health (in vitro) and enhances hair manageability. Produced through precision fermentation, PrimaColl is certified vegan, halal, Kosher, biodegradable and is versatile across skin care, hair care and beauty-from-within.

Rice Bran Ferment, Ichimaru Pharcos Co., Ltd.

Rice Bran Ferment is derived from rice bran through lactic acid fermentation, effectively upcycling a by-product of rice polishing in Japan. Inspired by "nukazuke," a traditional Japanese pickled food made through lactic acid fermentation, this ingredient reflects the wisdom of Japanese heritage. Rich in fine natural fibers, rice bran provides a gentle and interesting feeling on the skin. Fermentation significantly boosts its naturally occurring beauty components, including salicylic acid, suberic acid and azelaic acid. When formulated into cleansing products, it enhances cleansing efficacy, boosts skin hydration, refines skin texture and delivers a more pleasant sensory experience.

YouSIA, TS-Biotech

YouSIA is a cutting-edge biotechnology-derived acne care program designed for complete well-being. It targets the root causes of acne, effectively modulating sebum secretion, inhibiting C. acnes, mitigating inflammation and soothing sensitive areas. It also enhances the skin barrier for a harmonized skin tone: balancing hydration and sebum while restoring the cutaneous barrier, minimizing melanin accumulation in acne, and reducing pigmentation irregularities. Finally, it rebuilds confidence and self-esteem, extending beyond dermatological health to encompass emotional well-being. In particular, YouSIA enhances the positive neurotransmitter in individuals suffering from acne, to help them overcome the feeling of isolation closely associated with acne and to encourage social interaction.

Adesilnat, Exsymol

Adesilnat is a unique complex of adenosine and bioavailable silicium. The adenosine is derived through fermentation while the silicium comes from rice hulls, allowing Adesilnat to be 100% natural. Its efficacy on hair and skin has been assessed through clinical studies and in vitro testing for its effects on scalp oiliness, hair growth and skin wrinkles. By stimulating the autophagy pathway, this ingredient is capable of regenerating hair renewal, boosting its growth and preventing hair fall by maintaining hair's growth phase. Studies conducted in panelists experiencing telogen effluvium confirm its ability to target advanced stages of density loss.

BLH308 Botanical Complex, Bomme Corporation

BLH308 Botanical Complex is a patented botanical active that targets chronic scalp inflammation and follicle dysfunction, the root drivers of hair loss. Combining persimmon leaf, green tea EGCG, and sophora fruit extracts, BLH308 regulates 5-alpha-reductase and suppresses IL-6 while boosting Wnt3 expression to support follicle regeneration. In human clinical studies, a scalp toner with BLH308 reduced hair shedding by 71.6% and scalp redness by 16.5% in four weeks, while a shampoo with BLH308 reduced shedding by 65% and improved root volume by 25%. Safe for all scalp types, BLH308 establishes a new benchmark in topical hair/scalp treatments.

DandErase, Givaudan Active Beauty

DandErase is a revolutionary anti-dandruff ingredient derived from the exquisite saffron flower (Crocus sativus L.). This innovative active selectively combats Malassezia overgrowth while rebalancing the scalp microbiome, promoting holistic scalp health. Clinical trials reveal DandErase reduces dandruff by up to 95% in just three days, outperforming leading anti-dandruff shampoos. With 82% of consumers rating it superior to their current solutions, DandErase is more than an ingredient; it’s a transformative solution for healthier scalp and improved mood. Active in 100% of volunteers, the multifunctional is also gentle on the microbiome, boosts resilience and enhances positive emotions like happiness and relaxation.

Eterwell Hair, DSM-Firmenich

Multi-award winning Eterwell Hair is the first and only senolytic ingredient for hair and scalp care, revolutionizing root health at the cellular level. Harnessing groundbreaking senolytic science, it targets and clears senescent “zombie cells” — a key driver of hair aging — to restore balance, resilience and vitality to the scalp. By addressing the root causes of aging, Eterwell Hair slows hair decline, promoting density, longevity and s youthful appearance. This unique innovation transforms scalp care into cellular beauty, delivering rejuvenation for healthier, fuller and more resilient hair — setting a new standard in science-backed hair longevity solutions.

KeraBio K31, Croda Beauty

KeraBio K31 is a biotech powered biomimetic bond builder with pure, potent performance that delivers a vegan keratin recharge at the molecular level, elevating hair strength beyond repair. It's not just about temporarily fixing damage — it's about hair reaching its full potential with scientifically-backed, advanced bond building. Whether it's for hair damaged by chemical treatments or heat styling, or naturally fragile hair, KeraBio K31 delivers lasting results that surpass conventional hair repair solutions.

Polymeric Malassezia Inhibitor, Beauty Hi-Tech Innovation Co., Ltd.

A safe and non-penetrative polymeric Malassezia inhibitor was developed with a superior inhibitory effect compared to traditional small molecular actives such as ZPT and OCT. The polymeric active was synthesized by introducing tertiary amine groups at an optimized ratio onto an acrylate and methacrylate copolymer. A series of human safety tests, including 24-hr inclusive patch and repeat insult patch testing, indicated the polymer caused no skin irritation or sensitization. A shampoo prototype containing the polymer also showed significant anti-dandruff efficacy, opening a new door for future anti-dandruff innovation.

Purakan, Mane Kancor

Purakan is a revolutionary award-winning scalp care ingredient, developed by Mane Kancor to provide a natural anti-dandruff solution in place of zinc pyrithione. This unique, COSMOS-approved, patented formulation is a blend of 3 botanical extracts, each chosen for their specific benefits. What makes Purakan truly unique is that one of its ingredients is upcycled, while another supports 6,000 farmer families through a strong sustainability program that fosters backward integration. Purakan possesses antifungal properties that decrease the proliferation of Malassezia furfur while also significantly and visibly reducing dandruff — using the power of nature.

SymLash Xtreme, Symrise AG

Lashes embody beauty, but enhancement procedures often weaken them. SymLash XTreme is a patented, science-driven ingredient that delivers dramatic density — up to +35% in just 6 weeks, with visible improvement from week 2. Its powerful duo of next-gen lipopeptide and troxerutin stimulates keratin gene expression and shields follicles for fuller, healthier lashes. In a liquid, ready-to-use format, it fits seamlessly into modern cosmetic formulas. With proven efficacy and double-action innovation, SymLash XTreme redefines lash care.

TRI-K DensiFoll, TRI-K

DensiFoll is a 99% naturally derived bioactive powered by plant stem cell exosomes. This innovative ingredient stimulates key genes responsible for hair growth and promotes denser, thicker hair, making it ideal for formulations designed for thinning hair. DensiFoll also supports a healthy scalp environment by reinforcing the scalp’s barrier function for optimal follicle health.

100% Fermented Rose Hip Seed Oil (The Ordinary), DECIEM

The 100% Fermented Rose Hip Seed Oil is a breakthrough in bio-cosmetic innovation. This is the first fermented rosehip oil of its kind, with a unique, officially registered INCI name: Starmerella/Rosa Canina Seed Oil Ferment. Extensive analytical work confirms its enhanced properties. The fermentation process generates novel compounds, and clinical data from human skin explants show remarkable anti-inflammatory effects. The fermented oil significantly reduced LPS-induced IL-6 secretion — a key inflammation marker — with results comparable to dexamethasone, a known anti-inflammatory steroid. This validates fermentation as a powerful method to boost the bioactivity of natural oils, setting a new industry standard for enhanced skin care.

Activated Silk KDF-β, Evolved By Nature

Activated Silk KDF-β is a proactive rejuvenator for skin. The bioactive peptide boosts skin's natural baseline — so users start from a higher level of perfection against pollution, UV, stress and damage. The ingredient accelerates natural keratinocyte differentiation, flooding skin with five critical proteins including keratin, filaggrin and claudin, while increasing natural regeneration rates. The result? Stronger barrier, better hydration and increased resilience, plus visible repair from UV exposure, oxidative stress and dermatitis symptoms. Upcycled, cruelty-free and biodegradable, Activated Silk KDF-β is proof that sustainability and efficacy are natural allies: skin is rejuvenated and more resilient, while the planet gains critical support. Everybody wins.

Bioactive Totarol, Hyperganic Biogroup

Bioactive Totarol is redefining what a cosmetic active can achieve — delivering high-performance, multifunctional results while setting a new benchmark for sustainability. Clinically validated, it targets key skin concerns with proven outcomes: a 16% reduction in acne lesions, up to 30% less sebum for clearer skin, and measurable anti-aging benefits including a 13% reduction in wrinkle count and 6% reduction in wrinkle area. Its potent antimicrobial action eradicates Staphylococcus epidermidis at just 0.01% concentration, performing 25–100 times more effectively than conventional alternatives. A true innovation, Bioactive Totarol unites clinical breakthroughs with environmental integrity.

BioEssence K2 MK-7, Sino Lion USA

BioEssence K2 MK-7 (INCI: Menaquinone-7), also known as vitamin K2, addresses under-eye dark circles by helping the skin dissipate bruising and discoloration. The skin around the eye area is particularly delicate because it is extremely thin. Dark circles under the eyelids commonly occur because of the fragility of blood vessels. When the blood vessels break, blood leaks to the surrounding skin, resulting in eventual discoloration. Vitamin K is known primarily for its anti-coagulant property, which helps to regulate bleeding. It also helps in strengthening blood vessels to prevent breaking or damage.

Ferulishield Hemp, Midwest Bioprocessing Center

FeruliShield Hempseed Oil is a patented, bio-based ingredient that unites the antioxidant power of ferulic acid with the nourishing, non-comedogenic benefits of hemp seed oil. Produced via a proprietary enzymatic process, it enables stable, effortless incorporation of ferulic acid into modern skin care. This multifunctional active enhances formulation stability, protects sensitive ingredients like vitamins C and E, and amplifies SPF performance while defending against oxidative and free-radical damage. Over 80 times more biodegradable than petroleum-based alternatives, FeruliShield Hempseed Oil delivers exceptional performance with true environmental responsibility — where advanced biotechnology meets clean, sustainable skin care.

Galguard Prebiotive, Galaxy Surfactants Ltd.

Galguard Prebiotive is a 100% green antimicrobial preservative for personal care products. Chemically, it is N-capryloyl L-glutamine manufactured in pure form by green chemistry. Derived from bio-renewable sources like caprylic acid (vegetable oils) and L-glutamine (fermentation), it is biodegradable and cold-processable. It also exhibits a wide spectrum of antimicrobial activity across pH 4.0 to 7.0. As a prebiotic, it electively targets pathogenic bacteria (S. aureus) while being gentle on commensal bacteria (S. epidermidis), supporting skin microbiota. Galguard Prebiotive is especially suitable for formulations addressing eczema, acne, dandruff and body odor. The product is provided as a white, free-flowing powder.

MorinGuard, Lipoid Kosmetik AG

MorinGuard is a next-generation cosmetic active that transforms an overlooked by-product — moringa seed cake — into a powerful skin-soothing ingredient. Through sustainable upcycling, Lipoid Kosmetik has unlocked the bioactive potential of moringin, delivering dual action: reducing inflammation via NF-κB inhibition and boosting antioxidant defense through Nrf2 activation. Scientifically validated in vitro and in vivo, MorinGuard calms irritated skin, supports regeneration and strengthens the skin barrier. Its proven efficacy in real-life applications like post-microneedling is matched by its eco-conscious sourcing and social impact. MorinGuard exemplifies how innovation, sustainability and skin health can harmoniously converge in modern cosmetics.

SalSphere Even Skin, Salvona Technologies LLC

SalSphere Even Skin is a breakthrough encapsulated delivery system that refines skin texture, balances tone, and reduces blemishes with remarkable gentleness and efficacy. Using sub-micron spheres, it delivers pure salicylic acid precisely where it’s needed — on the skin’s surface and within pores — while minimizing irritation. This smart, sustained-release technology provides continuous exfoliation and sebum control for smoother, clearer, more radiant skin. Unlike conventional systems that rely on hard-to-dissolve acids, SalSphere Even Skin is easy to formulate, adheres to skin even after rinsing, and gradually releases actives for hours of comfort and performance. Made from natural, sustainable ingredients, it’s a cost-effective, next-generation solution.

SkinLipix HydraShield, Evonik

Traditional ceramides in cosmetics face challenges due to their low solubility in water and oils, often requiring high temperatures and a blend of oils to solubilize within the oil phase for incorporation into o/w emulsions. SkinLipix HydraShield, an innovative ceramide stabilization system, features two plant-oil-based ceramides produced through advanced biotechnological processes, combined with natural deep eutectic solvent-based moisturizers sorbitol and betaine. It strengthens both inner and outer skin barrier and boosts moisturization and hydration, restoring stratum corneum lipids, upregulating tight junction proteins, increasing the bound water content, and supporting water management through upregulated aquaporins.

Superoxide Dismutase 3 Enzyme Mist (NIOD), DECIEM

DECIEM's NIOD brand Superoxide Dismutase 3 Enzyme is a meticulously crafted formula, featuring a diverse blend of antioxidants like ergothioneine and oxidized glutathione, and showcasing a commitment to high-performing, science-backed skin care. This product’s significance lies in its pioneering use of a potent, previously unavailable ingredient, setting a new standard for antioxidant efficacy and demonstrating true industry leadership. DECIEM is in the process of becoming the first cosmetic company to successfully register the unique INCI for Superoxide Dismutase 3 (SOD3), establishing a new benchmark for advanced formulations.

TRI-K NiaPure, TRI-K Industries, Inc.

NiaPure is the next generation of low-irritation, high-performance niacinamide, expertly crafted to gently even skin tone, regulate sebum and visibly reduce hyperpigmentation. Developed through advanced fermentation technology and an exclusive technique to significantly enhance bioproduction efficiency, it delivers patented high purity and eliminates nicotinic acid for unparalleled skin comfort. With 10x less nicotinic acid compared to standard niacinamide, NiaPure minimizes melanin production while reducing irritation, making it ideal for sensitive and reactive skin.

Ziamozome, Dr. PONG Skin Research Lab Co., Ltd.

Ziamozome Targeted Liposome is a next-generation skin care technology clinically validated on Asian skin. Using smart, flexible liposomes with targeted ligands, it penetrates deeply to deliver actives directly to melanocytes, activating them internally to maximize whitening precisely where it is needed. This advanced system combines three synergistic actives at optimized concentrations, delivering +6% whitening, +24% brightness, –4% melanin reduction and +3% firmness improvement. With higher active loading and encapsulation than traditional liposomes, it ensures superior stability and long-lasting efficacy with a lightweight, comfortable feel. Clinically proven to be non-irritating, safe and effective, it sets a new benchmark for precision whitening and high-performance skin care.